Yes, you can run multiple containers using skypilot with docker-compose on a single GPU node. In the run section of your skypilot YAML file, you can have multiple docker run commands or use docker compose up if you have a docker-compose file. Here's an example:

  docker run ... & 
  docker run ...```

Alternatively, you can directly use `docker compose up` in the `run` section. See [example here](https://github.com/skypilot-org/skypilot/pull/2745/files).