Yes, you can use Ray Tune and have each trial call into SkyPilot's CLI sky spot launch or Python API. There are a few patterns you can follow:

• Launch 1 cluster and execute all trials on the cluster.
• Have each trial occupy its own cluster by using a control loop calling sky launch or sky spot launch for each trial.

The control loop can be implemented using a bash script, a simple Python script, or an HPO framework like Ray Tune.